Motif ID: HOX{A6,A7,B6,B7}.p2

Z-value: 2.504


Transcription factors associated with HOX{A6,A7,B6,B7}.p2:

Gene SymbolEntrez IDGene Name
HOXA6 3203 homeobox A6
HOXA7 3204 homeobox A7
HOXB6 3216 homeobox B6
HOXB7 3217 homeobox B7

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HOXB7chr17_-_466882790.359.8e-08Click!
HOXA7chr7_-_27196163-0.261.1e-04Click!
HOXB6chr17_-_466823330.242.9e-04Click!
HOXA6chr7_-_27187367-0.143.6e-02Click!


Activity profile for motif HOX{A6,A7,B6,B7}.p2.

activity profile for motif HOX{A6,A7,B6,B7}.p2


Sorted Z-values histogram for motif HOX{A6,A7,B6,B7}.p2

Sorted Z-values for motif HOX{A6,A7,B6,B7}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HOX{A6,A7,B6,B7}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_176733413 134.664 GPM6A
glycoprotein M6A
chr5_+_71502700 128.606 MAP1B
microtubule-associated protein 1B
chr4_-_176733901 108.318 GPM6A
glycoprotein M6A
chr3_+_159557745 102.510 SCHIP1
schwannomin interacting protein 1
chr12_-_16760935 95.751 NM_001001395
NM_001243609
LMO3

LIM domain only 3 (rhombotin-like 2)

chr3_+_158787040 89.347 NM_001197113
NM_001197114
NM_001042705
NM_001042706
NM_001197100
IQCJ-SCHIP1

IQCJ


IQCJ-SCHIP1 readthrough

IQ motif containing J


chr3_+_159557649 86.897 NM_001197109
SCHIP1
schwannomin interacting protein 1
chr17_-_1248346 73.329 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr21_-_27253197 71.971 APP
amyloid beta (A4) precursor protein
chr2_-_55237255 70.984 NM_007008
RTN4
reticulon 4
chr11_-_115088628 67.024 CADM1
cell adhesion molecule 1
chr9_-_14086901 62.696 NFIB
nuclear factor I/B
chr2_-_200325200 61.717 SATB2
SATB homeobox 2
chrX_-_137821514 58.491 NM_033642
FGF13
fibroblast growth factor 13
chr4_-_176734181 54.639 NM_201591
GPM6A
glycoprotein M6A
chr16_+_7382750 52.473 NM_145891
NM_145892
NM_145893
RBFOX1


RNA binding protein, fox-1 homolog (C. elegans) 1


chr1_+_151032866 50.836 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr4_+_41700736 50.082 LIMCH1
LIM and calponin homology domains 1
chr1_+_151032683 49.839 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr1_+_151032880 49.048 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr4_+_41614911 48.435 NM_001112719
NM_001112720
LIMCH1

LIM and calponin homology domains 1

chr2_-_175712276 47.592 NM_001206602
CHN1
chimerin (chimaerin) 1
chr22_-_36236264 45.450 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr22_-_36236330 45.395 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr22_-_36236421 43.917 NM_001031695
NM_001082576
NM_001082577
NM_014309
RBFOX2



RNA binding protein, fox-1 homolog (C. elegans) 2



chr20_+_11898536 43.072 NM_014962
BTBD3
BTB (POZ) domain containing 3
chr2_-_224467095 42.960 SCG2
secretogranin II
chr2_-_55199894 42.847


chr14_+_101295409 42.466 MEG3
maternally expressed 3 (non-protein coding)
chr1_+_50574601 40.279 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr12_-_16758312 39.665 NM_001243611
LMO3
LIM domain only 3 (rhombotin-like 2)
chr3_-_33700480 38.920 CLASP2
cytoplasmic linker associated protein 2
chr12_-_16759430 38.711 LMO3
LIM domain only 3 (rhombotin-like 2)
chr2_+_102508377 38.208 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr1_+_50574589 38.028 NM_001144774
NM_021952
ELAVL4

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)

chr2_-_216259197 37.529 FN1
fibronectin 1
chr5_+_36606667 37.519 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr5_+_140771482 37.322 NM_014004
NM_032088
PCDHGA8

protocadherin gamma subfamily A, 8

chr2_-_224467142 37.265 NM_003469
SCG2
secretogranin II
chr1_-_156399183 37.056 NM_006365
C1orf61
chromosome 1 open reading frame 61
chr3_+_35721115 37.013 NM_001025068
NM_001025069
ARPP21

cAMP-regulated phosphoprotein, 21kDa

chr1_+_50571963 36.841 NM_001144775
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr12_-_16758839 36.800 NM_001243612
LMO3
LIM domain only 3 (rhombotin-like 2)
chr1_+_84630014 36.410 NM_001242857
NM_001242858
NM_001242859
PRKACB


protein kinase, cAMP-dependent, catalytic, beta


chr1_+_50569581 36.211 NM_001144776
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr2_-_224467049 35.508 SCG2
secretogranin II
chr5_+_36606456 34.810 NM_001166696
NM_004172
SLC1A3

solute carrier family 1 (glial high affinity glutamate transporter), member 3

chrX_-_13835187 34.713 GPM6B
glycoprotein M6B
chr2_-_2334887 34.412 NM_015025
MYT1L
myelin transcription factor 1-like
chrX_-_13835012 34.084 GPM6B
glycoprotein M6B
chr18_-_21891469 33.094 NM_001242508
OSBPL1A
oxysterol binding protein-like 1A
chr2_-_216241321 33.080 FN1
fibronectin 1
chr9_+_97521930 33.020 NM_001193329
C9orf3
chromosome 9 open reading frame 3
chr1_+_84630374 32.616 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr8_+_80523351 32.462 STMN2
stathmin-like 2
chr4_+_88896801 32.127 NM_000582
NM_001040058
NM_001040060
NM_001251829
NM_001251830
SPP1




secreted phosphoprotein 1




chr12_-_16759531 32.036 NM_018640
LMO3
LIM domain only 3 (rhombotin-like 2)
chr12_-_16757944 31.857 LMO3
LIM domain only 3 (rhombotin-like 2)
chr4_+_88896899 31.733 SPP1
secreted phosphoprotein 1
chrX_-_13835313 31.540 NM_001001995
NM_001001996
NM_005278
GPM6B


glycoprotein M6B


chr4_+_88896868 31.082 SPP1
secreted phosphoprotein 1
chr4_+_88896838 30.594 SPP1
secreted phosphoprotein 1
chr8_+_80523376 30.232 STMN2
stathmin-like 2
chr4_+_41258895 30.115 NM_004181
UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr6_+_121756744 30.013 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr2_+_102508333 29.740 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr3_+_115342302 29.680 GAP43
growth associated protein 43
chr4_+_41614933 29.314 LIMCH1
LIM and calponin homology domains 1
chr5_+_140743755 29.311 NM_018918
NM_032054
PCDHGA5

protocadherin gamma subfamily A, 5

chr8_+_80523304 29.134 STMN2
stathmin-like 2
chr8_+_80523339 29.091 STMN2
stathmin-like 2
chr17_-_29624249 28.857 NM_002544
OMG
oligodendrocyte myelin glycoprotein
chr7_-_107880492 28.826 NM_001037132
NRCAM
neuronal cell adhesion molecule
chr4_+_113970784 28.635 NM_001148
NM_020977
ANK2

ankyrin 2, neuronal

chr8_+_104831415 28.631 NM_014677
RIMS2
regulating synaptic membrane exocytosis 2
chr8_+_80523048 28.506 NM_001199214
NM_007029
STMN2

stathmin-like 2

chr12_-_16759733 28.077 NM_001243610
LMO3
LIM domain only 3 (rhombotin-like 2)
chrX_+_135251795 27.819 NM_001167819
FHL1
four and a half LIM domains 1
chr17_-_8063946 27.375 VAMP2
vesicle-associated membrane protein 2 (synaptobrevin 2)
chr1_+_183114214 27.308 LAMC1
laminin, gamma 1 (formerly LAMB2)
chrX_+_135278912 27.070 NM_001159701
NM_001159699
FHL1

four and a half LIM domains 1

chr3_-_79817058 26.281 NM_002941
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chrX_-_72434623 26.203 NAP1L2
nucleosome assembly protein 1-like 2
chr9_-_8733893 25.883 NM_001040712
NM_001171025
NM_130391
NM_130392
NM_130393
PTPRD




protein tyrosine phosphatase, receptor type, D




chr10_+_102123420 25.797


chr1_+_84630575 25.725 NM_001242860
NM_001242861
PRKACB

protein kinase, cAMP-dependent, catalytic, beta

chrX_-_72434656 25.555 NAP1L2
nucleosome assembly protein 1-like 2
chr6_-_46293628 25.325 NM_005822
RCAN2
regulator of calcineurin 2
chr18_-_53089722 24.996 NM_001243233
TCF4
transcription factor 4
chr17_-_35656691 24.530 NM_198837
NM_198838
ACACA

acetyl-CoA carboxylase alpha

chr1_+_244214552 24.506 NM_205768
ZNF238
zinc finger protein 238
chrX_-_72434667 24.339 NM_021963
NAP1L2
nucleosome assembly protein 1-like 2
chrX_+_114827818 24.177 NM_001136025
NM_001172335
PLS3

plastin 3

chr15_+_91769329 24.117 SV2B
synaptic vesicle glycoprotein 2B
chr5_-_168271852 23.987


chr3_-_33700932 23.963 NM_001207044
CLASP2
cytoplasmic linker associated protein 2
chr8_-_120651019 23.699 NM_001040092
NM_001130863
NM_006209
ENPP2


ectonucleotide pyrophosphatase/phosphodiesterase 2


chrX_+_135251454 23.553 NM_001159704
FHL1
four and a half LIM domains 1
chr18_-_74691951 23.197 MBP
myelin basic protein
chr11_+_131240370 22.927 NM_001048209
NTM
neurotrimin
chr1_-_57045214 22.447 PPAP2B
phosphatidic acid phosphatase type 2B
chr1_-_86043932 22.337 NM_001134445
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr1_+_155853546 21.932 SYT11
synaptotagmin XI
chr12_-_50616425 21.804 NM_001113547
LIMA1
LIM domain and actin binding 1
chr13_+_36050885 21.758 NM_001204197
NBEA
neurobeachin
chr13_-_45010937 21.689 TSC22D1
TSC22 domain family, member 1
chr4_+_113739203 21.678 NM_001127493
ANK2
ankyrin 2, neuronal
chr10_-_118680978 21.374 KIAA1598
KIAA1598
chr4_+_41258909 21.287 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr4_+_41258941 21.125 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr4_+_41614725 21.048 LIMCH1
LIM and calponin homology domains 1
chr1_+_81771844 20.684 LPHN2
latrophilin 2
chr3_+_115342150 20.635 NM_001130064
NM_002045
GAP43

growth associated protein 43

chr3_+_111717585 20.537 NM_001008272
NM_013259
TAGLN3

transgelin 3

chr17_-_46687925 20.361 HOXB7
homeobox B7
chr13_-_103054027 19.874 NM_175929
FGF14
fibroblast growth factor 14
chr5_-_88119604 19.699 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr7_-_31380507 19.544 NM_022728
NEUROD6
neurogenic differentiation 6
chr3_+_35722428 19.438 NM_198399
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr11_+_69467210 19.399 CCND1
cyclin D1
chr12_-_71031174 19.238 NM_001109754
PTPRB
protein tyrosine phosphatase, receptor type, B
chr12_-_16759939 19.203 NM_001243613
LMO3
LIM domain only 3 (rhombotin-like 2)
chr6_+_158733691 18.993 NM_001007466
NM_020245
TULP4

tubby like protein 4

chr1_+_92632608 18.869 NM_015237
KIAA1107
KIAA1107
chr8_-_110655418 18.780 NM_001099756
SYBU
syntabulin (syntaxin-interacting)
chr11_-_111782447 18.695 NM_001885
CRYAB
crystallin, alpha B
chr7_+_134464161 18.544 NM_004342
NM_033138
NM_033157
CALD1


caldesmon 1


chr1_+_50575465 18.436 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr1_+_244214576 18.271 ZNF238
zinc finger protein 238
chr13_-_36429798 18.223 NM_001195415
NM_001195416
NM_001195430
DCLK1


doublecortin-like kinase 1


chr3_-_149095413 18.079 TM4SF1
transmembrane 4 L six family member 1
chr14_-_101036130 18.049 NM_020836
BEGAIN
brain-enriched guanylate kinase-associated homolog (rat)
chr15_+_43885251 18.018 NM_020990
CKMT1B
CKMT1A
creatine kinase, mitochondrial 1B
creatine kinase, mitochondrial 1A
chr10_+_95517565 17.831 NM_005097
LGI1
leucine-rich, glioma inactivated 1
chr6_-_136847078 17.693 NM_001198608
NM_001198609
NM_001198611
MAP7


microtubule-associated protein 7


chr3_-_149095458 17.606 TM4SF1
transmembrane 4 L six family member 1
chr6_+_83072922 17.561 NM_006670
TPBG
trophoblast glycoprotein
chr5_+_140753480 17.319 NM_018919
NM_032086
PCDHGA6

protocadherin gamma subfamily A, 6

chr3_-_196911001 17.315 NM_001204387
NM_001204388
DLG1

discs, large homolog 1 (Drosophila)

chr5_+_140762401 17.074 NM_018920
NM_032087
PCDHGA7

protocadherin gamma subfamily A, 7

chr8_-_18666295 16.987 NM_206909
PSD3
pleckstrin and Sec7 domain containing 3
chr3_-_149095333 16.839 TM4SF1
transmembrane 4 L six family member 1
chrX_-_13835213 16.694 GPM6B
glycoprotein M6B
chr12_+_79258588 16.671 SYT1
synaptotagmin I
chr7_+_134464417 16.659 CALD1
caldesmon 1
chr5_-_24645084 16.491 NM_006727
CDH10
cadherin 10, type 2 (T2-cadherin)
chr3_-_149095517 16.485 NM_014220
TM4SF1
transmembrane 4 L six family member 1
chr8_+_54764367 16.217 NM_170587
RGS20
regulator of G-protein signaling 20
chr10_-_21186530 16.046 NM_006393
NEBL
nebulette
chrX_-_32430370 15.998 NM_004011
NM_004012
DMD

dystrophin

chr1_-_57045129 15.970 PPAP2B
phosphatidic acid phosphatase type 2B
chr17_-_46688362 15.678 NM_004502
HOXB7
homeobox B7
chr11_-_27742224 15.631 NM_001143805
NM_001143806
NM_170732
BDNF


brain-derived neurotrophic factor


chr15_+_96869156 15.631 NM_001145155
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr8_-_102803196 15.521 NCALD
neurocalcin delta
chr1_-_244006471 15.521 NM_005465
NM_181690
AKT3

v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)

chr1_-_57045235 15.511 NM_003713
PPAP2B
phosphatidic acid phosphatase type 2B
chr12_+_79258517 15.349 SYT1
synaptotagmin I
chr12_-_90049818 15.294 NM_001001323
NM_001682
ATP2B1

ATPase, Ca++ transporting, plasma membrane 1

chr4_-_87028805 15.252 NM_138981
MAPK10
mitogen-activated protein kinase 10
chr4_+_158141735 15.239 NM_000826
NM_001083619
NM_001083620
GRIA2


glutamate receptor, ionotropic, AMPA 2


chr3_-_15839674 15.163 NM_001195098
ANKRD28
ankyrin repeat domain 28
chr8_-_110661007 15.043 NM_001099747
NM_001099748
NM_001099749
NM_001099750
NM_017786
SYBU




syntabulin (syntaxin-interacting)




chr13_-_45011389 14.898 NM_001243797
TSC22D1
TSC22 domain family, member 1
chr8_+_132991171 14.890 EFR3A
EFR3 homolog A (S. cerevisiae)
chr13_-_45011059 14.791 NM_006022
TSC22D1
TSC22 domain family, member 1
chr5_+_173472692 14.740 NM_015980
HMP19
HMP19 protein
chr1_+_65730423 14.673 NM_014787
DNAJC6
DnaJ (Hsp40) homolog, subfamily C, member 6
chr5_+_34687663 14.558 NM_001145523
RAI14
retinoic acid induced 14
chr17_-_46682333 14.541 NM_018952
HOXB6
homeobox B6
chr1_+_163038395 14.389 NM_001102445
RGS4
regulator of G-protein signaling 4
chr16_+_6823809 14.304 NM_001142334
RBFOX1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr3_+_128532267 14.268


chr3_+_238274 14.178 NM_001253387
NM_006614
CHL1

cell adhesion molecule with homology to L1CAM (close homolog of L1)

chr11_-_129062092 14.090 NM_001142685
ARHGAP32
Rho GTPase activating protein 32
chr8_-_102803178 14.076 NCALD
neurocalcin delta
chr8_-_18541441 14.006 PSD3
pleckstrin and Sec7 domain containing 3
chr11_+_73357222 13.743 NM_001130033
NM_021200
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr6_+_114178516 13.659 NM_002356
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr6_+_64286348 13.501 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr6_-_6007097 13.458 NRN1
neuritin 1
chr5_+_102201526 13.426 NM_000919
NM_001177306
NM_138766
NM_138821
NM_138822
PAM




peptidylglycine alpha-amidating monooxygenase




chr2_-_44586854 13.415 NM_001042385
NM_001042386
PREPL

prolyl endopeptidase-like

chr5_+_125695787 13.411 NM_001146319
GRAMD3
GRAM domain containing 3
chr3_-_123339178 13.216 MYLK
myosin light chain kinase
chrX_-_10851808 13.050 NM_033290
MID1
midline 1 (Opitz/BBB syndrome)
chr3_+_130569368 13.043 NM_001199180
NM_001199181
NM_001199182
ATP2C1


ATPase, Ca++ transporting, type 2C, member 1


chr2_-_122159140 12.978 CLASP1
cytoplasmic linker associated protein 1
chrX_-_10535476 12.974 NM_001193278
NM_001193279
NM_001193280
NM_001193281
MID1



midline 1 (Opitz/BBB syndrome)



chr10_-_62149487 12.960 NM_020987
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr12_-_45307710 12.948 NM_001145110
NELL2
NEL-like 2 (chicken)
chr20_+_10199455 12.853 NM_003081
NM_130811
SNAP25

synaptosomal-associated protein, 25kDa

chr5_+_71403040 12.640 NM_005909
MAP1B
microtubule-associated protein 1B
chr15_-_37391893 12.551 MEIS2
Meis homeobox 2
chr2_+_210444154 12.528 MAP2
microtubule-associated protein 2
chr1_+_84609941 12.490 NM_182948
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr12_+_119616594 12.472 NM_014365
HSPB8
heat shock 22kDa protein 8
chr2_-_200329810 12.446 NM_001172517
SATB2
SATB homeobox 2
chr17_+_44101549 12.441 MAPT
microtubule-associated protein tau
chr18_+_56530060 12.380 NM_018181
ZNF532
zinc finger protein 532

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.19 9.30e-34 GO:0009987 cellular process
1.60 1.93e-30 GO:0048731 system development
1.55 2.86e-29 GO:0048856 anatomical structure development
1.50 2.88e-27 GO:0007275 multicellular organismal development
1.47 1.71e-26 GO:0032502 developmental process
1.82 1.33e-25 GO:0007399 nervous system development
1.35 4.76e-24 GO:0032501 multicellular organismal process
1.25 5.44e-23 GO:0065007 biological regulation
1.44 1.16e-22 GO:0023052 signaling
1.25 9.96e-19 GO:0050794 regulation of cellular process
1.24 5.53e-18 GO:0050789 regulation of biological process
1.40 2.83e-16 GO:0007165 signal transduction
1.65 8.35e-16 GO:0009653 anatomical structure morphogenesis
1.25 1.24e-14 GO:0050896 response to stimulus
3.30 4.69e-14 GO:0007156 homophilic cell adhesion
1.79 2.68e-13 GO:0022008 neurogenesis
1.32 2.93e-13 GO:0051716 cellular response to stimulus
1.49 7.34e-13 GO:0030154 cell differentiation
1.48 7.58e-13 GO:0048869 cellular developmental process
1.86 8.39e-13 GO:0007155 cell adhesion
1.86 8.39e-13 GO:0022610 biological adhesion
1.80 9.53e-13 GO:0048699 generation of neurons
1.46 5.02e-12 GO:0048523 negative regulation of cellular process
1.50 7.03e-12 GO:0048513 organ development
2.36 1.32e-11 GO:0016337 cell-cell adhesion
1.72 5.41e-11 GO:0048468 cell development
1.80 5.67e-11 GO:0007267 cell-cell signaling
1.83 9.10e-11 GO:0030182 neuron differentiation
1.38 1.20e-10 GO:0048518 positive regulation of biological process
1.41 2.53e-10 GO:0048519 negative regulation of biological process
1.88 1.18e-09 GO:0048666 neuron development
1.39 1.64e-09 GO:0048522 positive regulation of cellular process
1.41 1.71e-09 GO:0065008 regulation of biological quality
1.94 2.30e-09 GO:0000904 cell morphogenesis involved in differentiation
1.83 2.42e-09 GO:0032989 cellular component morphogenesis
1.79 2.52e-09 GO:0045595 regulation of cell differentiation
1.63 3.06e-09 GO:0007154 cell communication
1.74 3.56e-09 GO:2000026 regulation of multicellular organismal development
1.63 5.69e-09 GO:0009605 response to external stimulus
1.83 9.63e-09 GO:0000902 cell morphogenesis
1.65 1.09e-08 GO:0050793 regulation of developmental process
1.62 1.99e-08 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.95 2.48e-08 GO:0051094 positive regulation of developmental process
1.38 2.48e-08 GO:0042221 response to chemical stimulus
1.66 2.63e-08 GO:0040011 locomotion
1.92 2.69e-08 GO:0072358 cardiovascular system development
1.92 2.69e-08 GO:0072359 circulatory system development
1.89 3.03e-08 GO:0031175 neuron projection development
1.94 3.61e-08 GO:0048812 neuron projection morphogenesis
1.53 5.27e-08 GO:0009893 positive regulation of metabolic process
1.61 5.59e-08 GO:0042127 regulation of cell proliferation
1.94 6.52e-08 GO:0048667 cell morphogenesis involved in neuron differentiation
1.76 6.80e-08 GO:0030030 cell projection organization
1.88 6.84e-08 GO:0019226 transmission of nerve impulse
1.88 6.84e-08 GO:0035637 multicellular organismal signaling
1.86 7.99e-08 GO:0032990 cell part morphogenesis
1.34 9.36e-08 GO:0071842 cellular component organization at cellular level
1.86 9.92e-08 GO:0048858 cell projection morphogenesis
1.29 2.00e-07 GO:0016043 cellular component organization
1.93 2.12e-07 GO:0007409 axonogenesis
1.72 2.42e-07 GO:0010628 positive regulation of gene expression
1.53 2.66e-07 GO:0010604 positive regulation of macromolecule metabolic process
1.90 3.48e-07 GO:0007268 synaptic transmission
1.67 4.33e-07 GO:0010557 positive regulation of macromolecule biosynthetic process
1.41 4.89e-07 GO:0007166 cell surface receptor linked signaling pathway
2.02 6.42e-07 GO:0007411 axon guidance
1.51 7.35e-07 GO:0031325 positive regulation of cellular metabolic process
1.61 9.46e-07 GO:0031328 positive regulation of cellular biosynthetic process
2.04 1.02e-06 GO:0060284 regulation of cell development
1.42 1.05e-06 GO:0023051 regulation of signaling
1.61 1.06e-06 GO:0009891 positive regulation of biosynthetic process
1.48 1.11e-06 GO:0051239 regulation of multicellular organismal process
1.31 1.41e-06 GO:0071841 cellular component organization or biogenesis at cellular level
1.99 1.87e-06 GO:0045597 positive regulation of cell differentiation
1.26 2.00e-06 GO:0071840 cellular component organization or biogenesis
1.63 3.06e-06 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.52 4.66e-06 GO:0010646 regulation of cell communication
1.25 6.61e-06 GO:0051179 localization
1.69 6.70e-06 GO:0045893 positive regulation of transcription, DNA-dependent
1.83 7.32e-06 GO:0032583 regulation of gene-specific transcription
1.60 7.86e-06 GO:0051173 positive regulation of nitrogen compound metabolic process
1.69 9.70e-06 GO:0009887 organ morphogenesis
1.43 1.31e-05 GO:0009966 regulation of signal transduction
1.74 1.80e-05 GO:0007417 central nervous system development
1.73 3.52e-05 GO:0048585 negative regulation of response to stimulus
1.72 3.77e-05 GO:0006935 chemotaxis
1.72 3.77e-05 GO:0042330 taxis
1.98 3.78e-05 GO:0001944 vasculature development
2.01 5.32e-05 GO:0001568 blood vessel development
1.24 6.88e-05 GO:0060255 regulation of macromolecule metabolic process
1.61 1.03e-04 GO:0007167 enzyme linked receptor protein signaling pathway
1.91 1.04e-04 GO:0022603 regulation of anatomical structure morphogenesis
1.67 1.06e-04 GO:0007186 G-protein coupled receptor protein signaling pathway
1.34 1.29e-04 GO:0048583 regulation of response to stimulus
1.60 1.55e-04 GO:0051254 positive regulation of RNA metabolic process
1.51 2.19e-04 GO:0009888 tissue development
1.44 3.56e-04 GO:0051246 regulation of protein metabolic process
1.56 4.10e-04 GO:0009790 embryo development
2.26 4.91e-04 GO:0043062 extracellular structure organization
1.65 4.98e-04 GO:0008284 positive regulation of cell proliferation
3.27 5.30e-04 GO:0070848 response to growth factor stimulus
1.71 5.35e-04 GO:0023057 negative regulation of signaling
1.71 6.03e-04 GO:0010648 negative regulation of cell communication
1.22 8.54e-04 GO:0080090 regulation of primary metabolic process
1.27 1.20e-03 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.87 1.43e-03 GO:0051960 regulation of nervous system development
2.81 1.47e-03 GO:0048638 regulation of developmental growth
1.96 1.69e-03 GO:0051129 negative regulation of cellular component organization
1.47 1.80e-03 GO:0006351 transcription, DNA-dependent
5.21 1.84e-03 GO:0007026 negative regulation of microtubule depolymerization
1.48 1.95e-03 GO:0051128 regulation of cellular component organization
1.89 2.01e-03 GO:0045596 negative regulation of cell differentiation
2.20 2.09e-03 GO:0034330 cell junction organization
3.50 2.12e-03 GO:0043242 negative regulation of protein complex disassembly
2.30 2.36e-03 GO:0010769 regulation of cell morphogenesis involved in differentiation
1.45 2.68e-03 GO:0009611 response to wounding
2.28 2.96e-03 GO:0022604 regulation of cell morphogenesis
1.19 3.19e-03 GO:0019222 regulation of metabolic process
1.26 3.21e-03 GO:0006950 response to stress
1.64 3.39e-03 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.72 3.46e-03 GO:0009792 embryo development ending in birth or egg hatching
1.25 3.68e-03 GO:0010556 regulation of macromolecule biosynthetic process
1.20 3.80e-03 GO:0031323 regulation of cellular metabolic process
1.68 3.98e-03 GO:0009968 negative regulation of signal transduction
1.72 4.12e-03 GO:0007420 brain development
1.55 4.24e-03 GO:0009725 response to hormone stimulus
2.62 4.48e-03 GO:0030178 negative regulation of Wnt receptor signaling pathway
2.40 4.59e-03 GO:0010720 positive regulation of cell development
4.90 4.59e-03 GO:0031114 regulation of microtubule depolymerization
2.01 4.73e-03 GO:0048732 gland development
1.71 5.25e-03 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.41 5.44e-03 GO:0032268 regulation of cellular protein metabolic process
1.88 5.50e-03 GO:0050767 regulation of neurogenesis
2.23 5.65e-03 GO:0030111 regulation of Wnt receptor signaling pathway
1.42 6.16e-03 GO:0032774 RNA biosynthetic process
1.54 7.58e-03 GO:0042060 wound healing
1.66 7.81e-03 GO:0016477 cell migration
1.69 8.43e-03 GO:0043009 chordate embryonic development
1.74 8.51e-03 GO:0051093 negative regulation of developmental process
1.24 8.54e-03 GO:0010468 regulation of gene expression
1.36 8.68e-03 GO:0010033 response to organic substance
1.22 8.93e-03 GO:0051234 establishment of localization
1.40 9.15e-03 GO:0042981 regulation of apoptosis
1.22 9.65e-03 GO:0006810 transport
1.87 9.77e-03 GO:0007507 heart development
1.64 9.86e-03 GO:0008285 negative regulation of cell proliferation
1.23 1.06e-02 GO:0031326 regulation of cellular biosynthetic process
1.86 1.13e-02 GO:0001558 regulation of cell growth
1.23 1.38e-02 GO:0009889 regulation of biosynthetic process
1.78 1.45e-02 GO:0061061 muscle structure development
2.78 1.45e-02 GO:0051494 negative regulation of cytoskeleton organization
1.39 1.56e-02 GO:0043067 regulation of programmed cell death
2.91 1.70e-02 GO:0050808 synapse organization
2.46 1.75e-02 GO:0030879 mammary gland development
1.78 1.79e-02 GO:0048545 response to steroid hormone stimulus
1.49 1.88e-02 GO:0009719 response to endogenous stimulus
1.91 2.05e-02 GO:0045664 regulation of neuron differentiation
1.93 2.18e-02 GO:0007584 response to nutrient
1.62 2.25e-02 GO:0040008 regulation of growth
1.37 2.70e-02 GO:0010941 regulation of cell death
1.28 2.90e-02 GO:0003008 system process
1.86 3.29e-02 GO:0048514 blood vessel morphogenesis
1.56 3.40e-02 GO:0009628 response to abiotic stimulus
1.58 3.42e-02 GO:0048870 cell motility
1.58 3.42e-02 GO:0051674 localization of cell
1.49 3.58e-02 GO:0048878 chemical homeostasis
2.88 3.61e-02 GO:0043244 regulation of protein complex disassembly
2.53 3.64e-02 GO:0022612 gland morphogenesis
1.64 3.89e-02 GO:0090066 regulation of anatomical structure size
2.29 4.06e-02 GO:0042176 regulation of protein catabolic process
1.39 4.35e-02 GO:0010605 negative regulation of macromolecule metabolic process
1.85 4.71e-02 GO:0043193 positive regulation of gene-specific transcription
1.56 4.99e-02 GO:0050801 ion homeostasis

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.43 3.32e-12 GO:0044459 plasma membrane part
1.27 5.26e-10 GO:0005886 plasma membrane
1.26 5.33e-10 GO:0071944 cell periphery
1.80 1.40e-09 GO:0030054 cell junction
1.14 1.52e-08 GO:0005737 cytoplasm
1.86 5.54e-07 GO:0045202 synapse
1.50 2.04e-06 GO:0044421 extracellular region part
2.08 3.44e-06 GO:0016323 basolateral plasma membrane
1.53 2.82e-05 GO:0005615 extracellular space
1.48 1.56e-04 GO:0005626 insoluble fraction
1.72 1.97e-04 GO:0009986 cell surface
1.68 4.24e-04 GO:0043005 neuron projection
1.47 4.24e-04 GO:0005624 membrane fraction
2.14 5.47e-04 GO:0005912 adherens junction
2.07 6.26e-04 GO:0070161 anchoring junction
1.36 7.50e-04 GO:0005887 integral to plasma membrane
1.27 1.00e-03 GO:0005829 cytosol
1.73 1.27e-03 GO:0005578 proteinaceous extracellular matrix
1.35 1.29e-03 GO:0031226 intrinsic to plasma membrane
1.66 1.81e-03 GO:0031012 extracellular matrix
1.41 3.28e-03 GO:0042995 cell projection
1.07 4.91e-03 GO:0044424 intracellular part
2.16 6.14e-03 GO:0030016 myofibril
1.70 7.14e-03 GO:0015629 actin cytoskeleton
2.00 7.60e-03 GO:0045211 postsynaptic membrane
2.09 8.93e-03 GO:0043292 contractile fiber
1.68 9.01e-03 GO:0044456 synapse part
2.18 9.21e-03 GO:0030055 cell-substrate junction
1.06 2.00e-02 GO:0005622 intracellular
1.32 2.10e-02 GO:0000267 cell fraction
2.74 3.16e-02 GO:0031093 platelet alpha granule lumen
1.38 4.06e-02 GO:0031410 cytoplasmic vesicle
2.68 4.29e-02 GO:0034774 secretory granule lumen
1.81 4.59e-02 GO:0030424 axon

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.26 7.40e-23 GO:0005515 protein binding
1.13 6.29e-18 GO:0005488 binding
1.91 1.67e-13 GO:0005509 calcium ion binding
1.55 1.11e-07 GO:0005102 receptor binding
1.65 7.62e-07 GO:0043565 sequence-specific DNA binding
1.48 2.36e-05 GO:0001071 nucleic acid binding transcription factor activity
1.48 2.36e-05 GO:0003700 sequence-specific DNA binding transcription factor activity
1.89 2.06e-04 GO:0032403 protein complex binding
4.42 2.34e-04 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
4.24 4.67e-04 GO:0004112 cyclic-nucleotide phosphodiesterase activity
1.59 4.82e-04 GO:0008092 cytoskeletal protein binding
1.71 5.85e-04 GO:0003712 transcription cofactor activity
3.03 6.24e-04 GO:0042562 hormone binding
1.70 6.58e-04 GO:0000988 protein binding transcription factor activity
1.70 6.58e-04 GO:0000989 transcription factor binding transcription factor activity
2.05 2.29e-03 GO:0008083 growth factor activity
5.05 2.32e-03 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity
1.85 3.14e-03 GO:0046982 protein heterodimerization activity
1.39 3.30e-03 GO:0030528 transcription regulator activity
1.69 5.54e-03 GO:0003779 actin binding
2.82 1.21e-02 GO:0003707 steroid hormone receptor activity
1.41 1.91e-02 GO:0019899 enzyme binding
5.05 2.53e-02 GO:0019002 GMP binding
1.43 3.02e-02 GO:0046983 protein dimerization activity
2.67 3.09e-02 GO:0004879 ligand-dependent nuclear receptor activity