Motif ID: HOX{A6,A7,B6,B7}.p2

Z-value: 2.504


Transcription factors associated with HOX{A6,A7,B6,B7}.p2:

Gene SymbolEntrez IDGene Name
HOXA6 3203 homeobox A6
HOXA7 3204 homeobox A7
HOXB6 3216 homeobox B6
HOXB7 3217 homeobox B7

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HOXB7chr17_-_466882790.359.8e-08Click!
HOXA7chr7_-_27196163-0.261.1e-04Click!
HOXB6chr17_-_466823330.242.9e-04Click!
HOXA6chr7_-_27187367-0.143.6e-02Click!


Activity profile for motif HOX{A6,A7,B6,B7}.p2.

activity profile for motif HOX{A6,A7,B6,B7}.p2


Sorted Z-values histogram for motif HOX{A6,A7,B6,B7}.p2

Sorted Z-values for motif HOX{A6,A7,B6,B7}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HOX{A6,A7,B6,B7}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_176733413 134.664 GPM6A
glycoprotein M6A
chr5_+_71502700 128.606 MAP1B
microtubule-associated protein 1B
chr4_-_176733901 108.318 GPM6A
glycoprotein M6A
chr3_+_159557745 102.510 SCHIP1
schwannomin interacting protein 1
chr12_-_16760935 95.751 NM_001001395
NM_001243609
 LMO3

LIM domain only 3 (rhombotin-like 2)

chr3_+_158787040 89.347 NM_001197113
NM_001197114
NM_001042705
NM_001042706
NM_001197100
 IQCJ-SCHIP1

IQCJ


IQCJ-SCHIP1 readthrough

IQ motif containing J


chr3_+_159557649 86.897 NM_001197109
 SCHIP1
schwannomin interacting protein 1
chr17_-_1248346 73.329 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr21_-_27253197 71.971 APP
amyloid beta (A4) precursor protein
chr2_-_55237255 70.984 NM_007008
 RTN4
reticulon 4
chr11_-_115088628 67.024 CADM1
cell adhesion molecule 1
chr9_-_14086901 62.696 NFIB
nuclear factor I/B
chr2_-_200325200 61.717 SATB2
SATB homeobox 2
chrX_-_137821514 58.491 NM_033642
 FGF13
fibroblast growth factor 13
chr4_-_176734181 54.639 NM_201591
 GPM6A
glycoprotein M6A
chr16_+_7382750 52.473 NM_145891
NM_145892
NM_145893
 RBFOX1


RNA binding protein, fox-1 homolog (C. elegans) 1


chr1_+_151032866 50.836 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr4_+_41700736 50.082 LIMCH1
LIM and calponin homology domains 1
chr1_+_151032683 49.839 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr1_+_151032880 49.048 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 173 entries
enrichment   p-value GO term description
5.21 1.84e-03 GO:0007026 negative regulation of microtubule depolymerization
4.90 4.59e-03 GO:0031114 regulation of microtubule depolymerization
3.50 2.12e-03 GO:0043242 negative regulation of protein complex disassembly
3.30 4.69e-14 GO:0007156 homophilic cell adhesion
3.27 5.30e-04 GO:0070848 response to growth factor stimulus
2.91 1.70e-02 GO:0050808 synapse organization
2.88 3.61e-02 GO:0043244 regulation of protein complex disassembly
2.81 1.47e-03 GO:0048638 regulation of developmental growth
2.78 1.45e-02 GO:0051494 negative regulation of cytoskeleton organization
2.62 4.48e-03 GO:0030178 negative regulation of Wnt receptor signaling pathway
2.53 3.64e-02 GO:0022612 gland morphogenesis
2.46 1.75e-02 GO:0030879 mammary gland development
2.40 4.59e-03 GO:0010720 positive regulation of cell development
2.36 1.32e-11 GO:0016337 cell-cell adhesion
2.30 2.36e-03 GO:0010769 regulation of cell morphogenesis involved in differentiation
2.29 4.06e-02 GO:0042176 regulation of protein catabolic process
2.28 2.96e-03 GO:0022604 regulation of cell morphogenesis
2.26 4.91e-04 GO:0043062 extracellular structure organization
2.23 5.65e-03 GO:0030111 regulation of Wnt receptor signaling pathway
2.20 2.09e-03 GO:0034330 cell junction organization

Gene overrepresentation in compartment category:

Showing 1 to 20 of 34 entries
enrichment   p-value GO term description
2.74 3.16e-02 GO:0031093 platelet alpha granule lumen
2.68 4.29e-02 GO:0034774 secretory granule lumen
2.18 9.21e-03 GO:0030055 cell-substrate junction
2.16 6.14e-03 GO:0030016 myofibril
2.14 5.47e-04 GO:0005912 adherens junction
2.09 8.93e-03 GO:0043292 contractile fiber
2.08 3.44e-06 GO:0016323 basolateral plasma membrane
2.07 6.26e-04 GO:0070161 anchoring junction
2.00 7.60e-03 GO:0045211 postsynaptic membrane
1.86 5.54e-07 GO:0045202 synapse
1.81 4.59e-02 GO:0030424 axon
1.80 1.40e-09 GO:0030054 cell junction
1.73 1.27e-03 GO:0005578 proteinaceous extracellular matrix
1.72 1.97e-04 GO:0009986 cell surface
1.70 7.14e-03 GO:0015629 actin cytoskeleton
1.68 4.24e-04 GO:0043005 neuron projection
1.68 9.01e-03 GO:0044456 synapse part
1.66 1.81e-03 GO:0031012 extracellular matrix
1.53 2.82e-05 GO:0005615 extracellular space
1.50 2.04e-06 GO:0044421 extracellular region part

Gene overrepresentation in function category:

Showing 1 to 20 of 25 entries
enrichment   p-value GO term description
5.05 2.32e-03 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity
5.05 2.53e-02 GO:0019002 GMP binding
4.42 2.34e-04 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
4.24 4.67e-04 GO:0004112 cyclic-nucleotide phosphodiesterase activity
3.03 6.24e-04 GO:0042562 hormone binding
2.82 1.21e-02 GO:0003707 steroid hormone receptor activity
2.67 3.09e-02 GO:0004879 ligand-dependent nuclear receptor activity
2.05 2.29e-03 GO:0008083 growth factor activity
1.91 1.67e-13 GO:0005509 calcium ion binding
1.89 2.06e-04 GO:0032403 protein complex binding
1.85 3.14e-03 GO:0046982 protein heterodimerization activity
1.71 5.85e-04 GO:0003712 transcription cofactor activity
1.70 6.58e-04 GO:0000988 protein binding transcription factor activity
1.70 6.58e-04 GO:0000989 transcription factor binding transcription factor activity
1.69 5.54e-03 GO:0003779 actin binding
1.65 7.62e-07 GO:0043565 sequence-specific DNA binding
1.59 4.82e-04 GO:0008092 cytoskeletal protein binding
1.55 1.11e-07 GO:0005102 receptor binding
1.48 2.36e-05 GO:0001071 nucleic acid binding transcription factor activity
1.48 2.36e-05 GO:0003700 sequence-specific DNA binding transcription factor activity